Wilforlide A( Wilforlide A | Regelide | Abruslactone A )

Catalog No. M19164 CAS No. 84104-71-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Wilforlide A
Note

Research use only, not for human use.
Brief Description

Wilforlide A is a natural product separated from the ethanolic extract of tripterygium wilfordii.
Description

Wilforlide A, also known as Regelide and Abruslactone A, is an active compound in Tripterygium wilfordii Hook F (TW) which is a traditional Chinese medicine for treatment of autoimmune diseases, is a quality control marker for TW product.
In Vitro

——
In Vivo

Wilforlide A (60-300 μg/kg) markedly inhibits mice auricular swelling induced by dimethylbenzene in ICR mice. Wilforlide A exhibits inhibition rates with 50.9% and 12.29% for high dose and low dose Wilforlide A, resepectively. Wilforlide A (30-150 μg/kg) markedly inhibits rat granulation induced by tampon.
Synonyms

Wilforlide A | Regelide | Abruslactone A
Pathway

Metabolic Enzyme/Protease
Target

Lipase
Recptor

Others
Research Area

Inflammation/Immunology
Indication

——

CAS Number

84104-71-2
Formula Weight

454.7
Molecular Formula

C30H46O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 1 mg/mL (2.20 mM)
SMILES

O[C@@H]1C(C)(C)[C@@H]2CC[C@@]3(C)[C@]4(C)CC[C@@]5(C)[C@H]6OC(=O)[C@](C)(C6)C[C@H]5C4=CC[C@@H]3[C@]2(CC1)C
Chemical Name

(2S,5S,5aR,7aS,7bR,9aR,11S,13aR,13bR,15bS)-11-hydroxy-2,5a,7a,7b,10,10,13a-heptamethyl-1,5,5a,6,7,7a,7b,8,9,9a,10,11,12,13,13a,13b,14,15b-octadecahydro-2,5-methanochryseno[2,1-c]oxepin-3(2H)-one

1. Xue M, et al. Fitoterapia. 2010 Dec;81(8):1109-12.

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